Apoptosis: Telling cells their time is up

@article{Nagata1996ApoptosisTC,
  title={Apoptosis: Telling cells their time is up},
  author={Shigekazu Nagata},
  journal={Current Biology},
  year={1996},
  volume={6},
  pages={1241-1243}
}
Ligand engagement by the receptor Fas leads to apoptosis. A clue to how this happens comes from the discovery that ligand binding leads to recruitment to Fas of a protease, homologous to interleukin-1 beta converting enzyme, likely to initiate a proteolytic cascade that drives apoptosis. 

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FLICE , A novel FADDhomologous ICE / CED3like protease , is recruited to the CD 95 ( Fas / APO1 ) deathinducing signaling complex

  • M Muzio, AM Chinn, +7 authors R Gentz
  • Cell
  • 1996

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