Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics

@article{Kerr1972ApoptosisAB,
  title={Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics},
  author={John F. R. Kerr and Andrew H. Wyllie and Alastair R. Currie},
  journal={British Journal of Cancer},
  year={1972},
  volume={26},
  pages={239 - 257}
}
The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations. Its morphological features suggest that it is an active, inherently programmed phenomenon, and it has been shown that it can be initiated or inhibited by a variety of environmental stimuli, both physiological and pathological.The structural changes take place in two discrete stages… Expand
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