Apoptosis, PCNA, and p53 in Fundulus grandis fish liver after in vivo exposure to N-methyl-N'-nitro-N-nitrosoguanidine and 2-aminofluorene.

Abstract

Dysfunction in homeostatic mechanisms of cell death and proliferation are considered to be important in the pathogenesis of chemically induced neoplasia. p53 has been implicated in the regulation of cell death and proliferation. To determine whether expression of apoptosis, proliferating cell nuclear antigen (PCNA), and p53 differ between an alkylating… (More)

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