Apoptosis, Axonal Growth Defects, and Degeneration of Peripheral Neurons in Mice Lacking CREB

  title={Apoptosis, Axonal Growth Defects, and Degeneration of Peripheral Neurons in Mice Lacking CREB},
  author={Bonnie E Lonze and Antonella Riccio and Sonia Cohen and David D Ginty},
CRE-binding protein (CREB) belongs to a family of transcription factors that mediates stimulus-dependent gene expression in neuronal and non-neuronal cells. Here we show that CREB is phosphorylated on its transcriptional regulatory site, Ser-133, in vivo in a neurotrophin-dependent manner. In mice harboring a null mutation in the Creb gene, sensory neurons exhibit excess apoptosis and degeneration, and display impaired axonal growth and projections. Interestingly, excess apoptosis is not… CONTINUE READING
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Targeted mutation

  • E. Hummler, T. J. Cole, +5 authors G. Schutz
  • 1994
Highly Influential
5 Excerpts

Requirement of neuroin mammalian cells

  • W. M. ElShamy, P. Ernfors
  • Proc. Natl. Acad. Sci. USA
  • 1996
Highly Influential
13 Excerpts

axonal processes after 1 DIV were scored. For assessment

  • A. axonal Bonni, D. D. Ginty, H. Dudek, M. E. Greenberg
  • Serine
  • 1995
Highly Influential
4 Excerpts

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