Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition.

@article{Kristal1999ApoptogenicGG,
  title={Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition.},
  author={Bruce S. Kristal and Arthur M. Brown},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 33},
  pages={23169-75}
}
Early events in apoptotic cascades initiated by ceramides or by activation of the surface receptor CD95 (Fas/APO-1) include the formation of ganglioside GD3. GD3 appears to be both necessary and sufficient to propagate this lipid-mediated apoptotic pathway. Later events common to many apoptotic pathways include induction of the mitochondrial permeability transition (PT) and cytochrome c release, which in turn triggers downstream caspases and cell death. The links between GD3 formation and… CONTINUE READING

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