Apoptin protein multimers form distinct higher-order nucleoprotein complexes with DNA.

@article{Leliveld2003ApoptinPM,
  title={Apoptin protein multimers form distinct higher-order nucleoprotein complexes with DNA.},
  author={Sirik Rutger Leliveld and Remus T Dame and Mieke A. Mommaas and Henk K. Koerten and C. Wyman and Astrid A A M Danen-van Oorschot and Jennifer Rohn and Mathieu H. M. Noteborn and Jan Pieter Abrahams},
  journal={Nucleic acids research},
  year={2003},
  volume={31 16},
  pages={4805-13}
}
The chicken anaemia virus-derived protein apoptin is a tumour-specific cell-killing agent. It is biologically active as a highly stable, multimeric complex, consisting of 30-40 monomers. In tumour cells, but negligibly in normal cells, apoptin is imported into the nucleus prior to the induction of apoptosis. Immunoelectron microscopic data we report here indicate that apoptin predominantly co-localises with heterochromatin and nucleoli within tumour cells. Apoptin's preference for these DNA… CONTINUE READING

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