Apoptin enhances the oncolytic activity of vaccinia virus in vitro

  title={Apoptin enhances the oncolytic activity of vaccinia virus in vitro},
  author={Galina Kochneva and Irina N. Babkina and Tatyana Lupan and Antonina Grazhdantseva and Peter V. Yudin and Galina Sivolobova and Alexander N. Shvalov and Evgueni Popov and Igor V. Babkin and Sergei V. Netesov and Peter M Chumakov},
  journal={Molecular Biology},
The chicken anemia virus gene that encodes apoptin, a selective killer of cancer cells, was synthe-sized and inserted into the vaccinia virus (strain L-IVP) genome. The insertion replaces a major part of the viral C11R gene that encodes viral growth factor, which is important for virulence. The recombinant virus VVdGF-ApoS24/2 was obtained by transient dominant selection using the gene of puromycin resistance as a selective marker. The expression of the apoptin gene from a synthetic early-late… CONTINUE READING
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Oncolytic viruses: Achievements and problems. Epidemiol

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Oncolytic viruses : Achievements and problems

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