Apomorphine offers new insight into dopaminergic neuron vulnerability in mesencephalic cultures.


The mechanism by which the dopamine neurons of the substantia nigra pars compacta degenerate in Parkinson's disease, is partly unknown. Dopamine could be implicated in this phenomenon, and in order to explain its toxicity several hypotheses have been suggested. The similarity between apomorphine and dopamine as regards their chemical, pharmacological and… (More)
DOI: 10.1016/j.neuropharm.2008.06.041