Apomorphine-induced flavor-drug associations: a dose-response analysis by the taste reactivity test and the conditioned taste avoidance test.

Abstract

Apomorphine is a positively reinforcing drug at low to moderate doses, but appears to lose its reinforcing properties at higher doses. In Experiment 1, across a range of doses (0.5-15.0 mg/kg, intraperitoneally), apomorphine produced a CTA over 5 conditioning/testing trials which was not dose-dependent by a single bottle test. The rejection taste reactivity… (More)

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