Apomorphine-induced blinking and yawning in healthy volunteers.

  title={Apomorphine-induced blinking and yawning in healthy volunteers.},
  author={Olivier Blin and Gerald Masson and Jean Philippe Azulay and J A Fondarai and Georges Serratrice},
  journal={British journal of clinical pharmacology},
  volume={30 5},
Yawning and spontaneous blink rate (SBR) are two physiological reflexes which have been incompletely examined but one neurobiological step of these two behaviours seems, at least in part, dopamine-dependent. The reference dopaminergic agonist, apomorphine hydrochloride (0.5, 1, and 2 micrograms kg-1 s.c.), was compared with a placebo in a double-blind latin-square design, and was shown to induce yawning and increase SBR in a population of eight healthy volunteers. These two behavioral effects… CONTINUE READING

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