Apomorphine-induced biphasic circling behaviour in 6-hydroxydopamine-lesioned rats

  • David M. Coward
  • Published 1983 in Naunyn-Schmiedeberg's Archives of Pharmacology


Factors governing the development of apomorphine-induced biphasic circling behaviour in rats having unilateral 6-hydroxydopamine lesions of the substantia nigra were investigated. It was found that a post-lesion time of at least 2–3 weeks and the repeated exposure to apomorphine were essential for its development. Optimal results were obtained when animals… (More)
DOI: 10.1007/BF00498827

6 Figures and Tables


  • Presentations referencing similar topics