Apomorphin bei der Behandlung des Morbus Parkinson

@article{Dreler2004ApomorphinBD,
  title={Apomorphin bei der Behandlung des Morbus Parkinson},
  author={D. Dre{\ss}ler},
  journal={Der Nervenarzt},
  year={2004},
  volume={76},
  pages={681-689}
}
ZusammenfassungApomorphin ist ein seit langem bekannter hochpotenter D2-, D3- und D4-Dopaminrezeptoragonist, der sich besonders durch eine zusätzliche D1-Dopaminrezeptorwirkung auszeichnet und in der Medizin vielfältige Anwendung gefunden hat. Wegen einer weitestgehenden Inaktivierung bei der Leberpassage wird Apomorphin in der Regel subkutan angewendet. Nach raschem Wirkungseintritt ist die Wirkungsdauer auf etwa eine Stunde begrenzt. Bei seiner Wirkung ist Apomorphin unabhängig von… 
4 Citations
Intermittierende Apomorphin-Injektionen als Rescue-Therapie beim fortgeschrittenen M. Parkinson
TLDR
Intermittent subcutaneous apomorphine therapy should be considered in patients with advanced Parkinson’s disease who experience recurrent off periods despite optimised oral treatment, for reliable and quick reversal of these otherwise refractory periods.
Antidopaminergic therapy for managing comorbidities in patients with Parkinson's disease.
TLDR
Although clozapine can be used to treat psychosis in patients with PD, managing nausea, vomiting, hiccups, and emergent psychotic symptoms in these patients remains a challenge due to a lack of evidence for currently available options.
[Intermittent apomorphine injections as rescue therapy for advanced Parkinson's disease. Consensus statement].
TLDR
Intermittent subcutaneous apomorphine therapy should be considered in patients with advanced Parkinson's disease who experience recurrent off periods despite optimised oral treatment, based on existing study results, indications, and contraindications.
Ventricular Bigeminy after Subcutaneous Administration of Apomorphine in a Patient with Refractory Parkinson’s Disease: A Case Report
TLDR
A case of ventricular bigeminy recorded in a female patient after the administration of apomorphine is reported, and it is reported that this is the first case reported in the literature of this type of treatment for Parkinson’s disease.

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