Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation

@article{Lopergolo2009ApollonGS,
  title={Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation},
  author={Alessia Lopergolo and Marzia Pennati and Paolo Gandellini and Nicola Ivan Orlotti and Paola Poma and M. G. Daidone and Marco Folini and Nadia Zaffaroni},
  journal={British Journal of Cancer},
  year={2009},
  volume={100},
  pages={739 - 746}
}
We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway… CONTINUE READING

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