Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro.

@article{Mulder2014ApolipoproteinsEA,
  title={Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro.},
  author={Sandra D. Mulder and Henrietta M. Nielsen and Marinus A. Blankenstein and Piet Eikelenboom and Robert Veerhuis},
  journal={Glia},
  year={2014},
  volume={62 4},
  pages={493-503}
}
Defective clearance of the amyloid-β peptide (Aβ) from the brain is considered a strong promoter in Alzheimer's disease (AD) pathogenesis. Astrocytes and microglia are important mediators of Aβ clearance and Aβ aggregation state and the presence of amyloid associated proteins (AAPs), such as Apolipoproteins E and J (ApoE and ApoJ), may influence Aβ clearance by these cells. Here we set out to investigate whether astrocytes and microglia differ in uptake efficiency of Aβ oligomers (Aβoligo ) and… CONTINUE READING