Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures.

@article{Kosacka2009ApolipoproteinsDA,
  title={Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures.},
  author={Joanna Kosacka and Martin Gericke and Marcin S Nowicki and Johannes Kacza and J{\"u}rgen Borlak and Katherina Spanel-Borowski},
  journal={Neuroscience},
  year={2009},
  volume={162 2},
  pages={282-91}
}
Co-cultures of 3T3-L1 adipocytes with neurons from the rat dorsal root ganglia (DRG) showed enhanced neuritogenesis and synaptogenesis. Microarray analysis for upregulated genes in adipocyte/DRG co-cultures currently points to apolipoproteins D and E (ApoD, ApoE) as influential proteins. We therefore tested adipocyte-secreted cholesterol and the carrier… CONTINUE READING