ApolipoproteinE ε 4 allelic variant , cognitive decline and psychosis in Alzheimer disease : a review of the literature and suggestions for upcoming studies

Abstract

Apolipoprotein E (ApoE) ε4 allele represents a well known vascular risk factor for developing Alzheimer disease (AD) and differences in ApoE genotypes may explain a part of the variability in AD phenotypes. In fact, ApoE ε4 allele possession seems to be associated with a more precocious age of onset, greater episodic memory impairment, and psychotic… (More)

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