Apolipoprotein e genotype, cortisol, and cognitive function in community-dwelling older adults.

@article{Lee2008ApolipoproteinEG,
  title={Apolipoprotein e genotype, cortisol, and cognitive function in community-dwelling older adults.},
  author={Brian K Lee and Thomas Glass and Gary Wand and Matthew J. McAtee and K. Bandeen-Roche and Karen I. Bolla and Brian S. Schwartz},
  journal={The American journal of psychiatry},
  year={2008},
  volume={165 11},
  pages={1456-64}
}
BACKGROUND Elevated cortisol indicates stress and may be a risk factor for cognitive decline in aging. Genetic factors may influence individual vulnerability to the adverse effects of stress on cognitive function in aging. METHOD The authors investigated whether the gene-environment interaction between the genotype for the apolipoprotein E gene (APOE) and cortisol predicted cognitive performance in older urban adults. Cross-sectional data were analyzed from a population-based sample of 50-70… CONTINUE READING