Apolipoprotein binding to protruding membrane domains during removal of excess cellular cholesterol.

@article{Lin2000ApolipoproteinBT,
  title={Apolipoprotein binding to protruding membrane domains during removal of excess cellular cholesterol.},
  author={Guorong Lin and John F. Oram},
  journal={Atherosclerosis},
  year={2000},
  volume={149 2},
  pages={
          359-70
        }
}
High-density lipoproteins (HDL) are believed to protect against cardiovascular disease by removing excess cholesterol from cells. Lipid-free HDL apolipoproteins remove cellular cholesterol and phospholipids by an active, Golgi-dependent process that is still poorly understood. Here we characterized the morphology of apolipoprotein binding sites on cultured cells by immunogold electron microscopy. After 6 h incubations with lipid-free apoA-I or apoE, immunogold-labeled apolipoproteins were… CONTINUE READING
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