Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart.

  title={Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart.},
  author={Annie Turkieh and C{\'e}line Caub{\`e}re and Manon Barutaut and Franck Desmoulin and Romain Harmancey and Michel Galinier and Matthieu Berry and Camille Dambrin and Carlo Polidori and Louis Casteilla and François Koukoui and Philippe Rouet and Fatima Smih},
  journal={The Journal of clinical investigation},
  volume={124 5},
Diabetic cardiomyopathy is a secondary complication of diabetes with an unclear etiology. Based on a functional genomic evaluation of obesity-associated cardiac gene expression, we previously identified and cloned the gene encoding apolipoprotein O (APOO), which is overexpressed in hearts from diabetic patients. Here, we generated APOO-Tg mice, transgenic mouse lines that expresses physiological levels of human APOO in heart tissue. APOO-Tg mice fed a high-fat diet exhibited depressed… CONTINUE READING
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