Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells.

@article{Zhaorigetu2011ApolipoproteinLI,
  title={Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells.},
  author={Siqin Zhaorigetu and Zhaoqing Yang and Ian Toma and Timothy A. McCaffrey and Chien-an A. Hu},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 31},
  pages={27389-98}
}
Inflammatory cytokine-regulated apoptosis and autophagy play pivotal roles in plaque rupture and thrombosis of atherosclerotic lesions. However, the molecular interplay between apoptosis and autophagy in vascular cells has not been investigated. Our prior study showed that human apolipoprotein L6 (ApoL6), a pro-apoptotic BH3-only member of the Bcl-2 family, was one of the downstream targets of interferon-γ (INFγ), which sensitizes atherosclerotic lesion-derived cells (LDCs) to Fas-induced… CONTINUE READING

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