Apolipoprotein L1 confers pH-switchable ion permeability to phospholipid vesicles.

Abstract

Apolipoprotein L1 (ApoL1) is a human serum protein conferring resistance to African trypanosomes, and certain ApoL1 variants increase susceptibility to some progressive kidney diseases. ApoL1 has been hypothesized to function like a pore-forming colicin and has been reported to have permeability effects on both intracellular and plasma membranes. Here, to… (More)
DOI: 10.1074/jbc.M117.813444

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