Apolipoprotein J (clusterin) and Alzheimer's disease.

  title={Apolipoprotein J (clusterin) and Alzheimer's disease.},
  author={Monica Calero and Agueda Rostagno and Etsuro Matsubara and Berislav V Zlokovic and Blas Frangione and Jorge Ghiso},
  journal={Microscopy research and technique},
  volume={50 4},
Apolipoprotein J (clusterin) is a ubiquitous multifunctional glycoprotein capable of interacting with a broad spectrum of molecules. In pathological conditions, it is an amyloid associated protein, co-localizing with fibrillar deposits in systemic and localized amyloid disorders. In Alzheimer's disease, the most frequent form of amyloidosis in humans and the major cause of dementia in the elderly, apoJ is present in amyloid plaques and cerebrovascular deposits but is rarely seen in NFT… CONTINUE READING