• Biology, Medicine
  • Published in
    The American journal of…
    1996

Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury.

@article{Swertfeger1996ApolipoproteinJI,
  title={Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury.},
  author={Debi K. Swertfeger and David P. Witte and William D. Stuart and Howard A. Rockman and Judith A. K. Harmony},
  journal={The American journal of pathology},
  year={1996},
  volume={148 6},
  pages={
          1971-83
        }
}
The function of apolipoprotein J (apoJ) is unknown, but it has been hypothesized to be cytoprotective. In the normal heart, abundant apoJ mRNA and protein are expressed in atrial myocytes; no expression is detected in ventricular myocytes. To provide clues about the role of apoJ in the heart, the response of apoJ to heart disease, including three models of myocarditis and two models of in vivo pressure overload hypertrophy, were examined. In the disease model studied extensively, myosin-induced… CONTINUE READING

Citations

Publications citing this paper.
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Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis.

  • The Journal of clinical investigation
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  • American journal of physiology. Heart and circulatory physiology
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HIGHLY INFLUENCED