Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

@article{Nakamura2009ApolipoproteinE,
  title={Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells},
  author={Toshiyuki Nakamura and Atsushi Watanabe and Takahiro Fujino and Takashi Hosono and Makoto Michikawa},
  journal={Molecular Neurodegeneration},
  year={2009},
  volume={4},
  pages={35 - 35}
}
Apolipoprotein E allele ε4 (apoE4) is a strong risk factor for developing Alzheimer's disease (AD). Secreted apoE has a critical function in redistributing lipids among central nervous system cells to maintain normal lipid homeostasis. In addition, previous reports have shown that apoE4 is cleaved by a protease in neurons to generate apoE4(1–272) fragment, which is associated with neurofibrillary tanglelike structures and mitochondria, causing mitochondrial dysfunction. However, it still… CONTINUE READING

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