Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice

@article{Maezawa2006ApolipoproteinEI,
  title={Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice},
  author={Izumi Maezawa and Nobuyo N. Maeda and Thomas J. Montine and Kathleen S. Montine},
  journal={Journal of Neuroinflammation},
  year={2006},
  volume={3},
  pages={10 - 10}
}
Inheritance of the three different alleles of the human apolipoprotein (apo) E gene (APOE) are associated with varying risk or clinical outcome from a variety of neurologic diseases. ApoE isoform-specific modulation of several pathogenic processes, in addition to amyloid β metabolism in Alzheimer's disease, have been proposed: one of these is innate immune response by glia. Previously we have shown that primary microglia cultures from targeted replacement (TR) APOE mice have apoE isoform… CONTINUE READING

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