Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

  title={Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides},
  author={Milla Koistinaho and Suizhen Lin and Xin Di Wu and Michail A. Esterman and Deanna Koger and Jeffrey W. Hanson and Richard E. Higgs and Feng Liu and Seema Malkani and Kelly R. Bales and Steven M Paul},
  journal={Nature Medicine},
We have previously shown that apolipoprotein E (Apoe) promotes the formation of amyloid in brain and that astrocyte-specific expression of APOE markedly affects the deposition of amyloid-β peptides (Aβ) in a mouse model of Alzheimer disease. Given the capacity of astrocytes to degrade Aβ, we investigated the potential role of Apoe in this astrocyte-mediated degradation. In contrast to cultured adult wild-type mouse astrocytes, adult Apoe−/− astrocytes do not degrade Aβ present in Aβ plaque… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 224 extracted citations


Publications referenced by this paper.
Showing 1-10 of 37 references

Microglia enhance β - amyloid peptide – induced toxicity in cortical and mes - encephalic neurons by producing reactive oxygen species

  • Y. Shao, K. D. McCarthy
  • J . Neurochem .
  • 2002

and inflammatory mechanisms in the clearance of amyloid β peptide

  • H. M. Wisniewski, J. Wegiel, K. C. Wang, M. Kujawa, B. Lach
  • Microglia
  • 2002

Similar Papers

Loading similar papers…