Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene.

@article{Copin2002ApolipoproteinES,
  title={Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene.},
  author={Bruno Copin and Antoine Pierre Br{\'e}zin and Françoise Valtot and J C Dascotte and Alain B{\'e}chetoille and Henri-Jean Garchon},
  journal={American journal of human genetics},
  year={2002},
  volume={70 6},
  pages={1575-81}
}
Primary open-angle glaucoma (POAG) is an optic neuropathy that has a high worldwide prevalence and that shows strong evidence of complex inheritance. The myocilin (MYOC) gene is the only one that has thus far been shown to have mutations in patients with POAG. Apolipoprotein E (APOE) plays an essential role in lipid metabolism, and the APOE gene has been involved in neuronal degeneration that occurs in Alzheimer disease (AD). Here, we report that two APOE-promoter single-nucleotide… CONTINUE READING
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