Apolipoprotein E promoter and alpha2-macroglobulin polymorphisms are not genetically associated with Chinese late onset Alzheimer's disease.

@article{Chen1999ApolipoproteinEP,
  title={Apolipoprotein E promoter and alpha2-macroglobulin polymorphisms are not genetically associated with Chinese late onset Alzheimer's disease.},
  author={Lei Chen and Larry S. Baum and Ho Keung Ng and Louie Loh Yen Chan and Isabel Sastre and Mar{\'i}a Jes{\'u}s Artiga and Fernando Valdivieso and Mar{\'i}a J Bullido and Helen Fung Kum Chiu and Chi Pui Pang},
  journal={Neuroscience letters},
  year={1999},
  volume={269 3},
  pages={173-7}
}
In this study, we investigated two newly reported polymorphisms in association with late onset Alzheimer's disease (AD) in Chinese. They were a -491 A/T polymorphism in the Apolipoprotein E (APOE) promoter region and a five base pair deletion at exon 18 of alpha2-Macroglobin (A2M). There were 196 AD and 180 normal controls (N), which were age- and sex-matched. APOE epsilon4 alleles were significantly increased in AD vs. N (chi2 = 33.3, P < 0.000001). However, neither the -491 A/T (chi2 = 1.13… CONTINUE READING

From This Paper

Topics from this paper.
15 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…