Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review.

  title={Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review.},
  author={June E. Eichner and Samuel Terence Dunn and Ghazala Perveen and David M. Thompson and Kenneth E Stewart and Berrit C Stroehla},
  journal={American journal of epidemiology},
  volume={155 6},
This review examines the association between the apolipoprotein (apo) var epsilon gene polymorphism (or its protein product (apo E)), metabolic regulation of cholesterol, and cardiovascular disease. The apo var epsilon gene is located at chromosome 19q13.2. Among the variants of this gene, alleles (*) epsilon2, (*) epsilon3, and (*) epsilon4 constitute the common polymorphism found in most populations. Of these variants, apo (*) epsilon3 is the most frequent (>60%) in all populations studied… CONTINUE READING
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