Apolipoprotein E polymorphism and brain morphology in mild cognitive impairment.

@article{Thomann2008ApolipoproteinEP,
  title={Apolipoprotein E polymorphism and brain morphology in mild cognitive impairment.},
  author={Philipp A. Thomann and Ann-Sophie Roth and Vasco Dos Santos and Pablo J Toro and Marco Essig and Johannes Schr{\"o}der},
  journal={Dementia and geriatric cognitive disorders},
  year={2008},
  volume={26 4},
  pages={300-5}
}
BACKGROUND The apolipoprotein E (ApoE) genotype has been confirmed as the major genetic risk factor for late-onset Alzheimer's disease (AD). How the ApoE genotype and brain morphology relate to each other is only partly understood, particularly in mild cognitive impairment, the assumed prestage of AD. METHODS A total of 83 subjects with mild cognitive impairment (aging-associated cognitive decline criteria) were investigated with optimized voxel-based morphometry (VBM). We tested for… CONTINUE READING
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