Apolipoprotein E polymorphism and Alzheimer's disease.

  title={Apolipoprotein E polymorphism and Alzheimer's disease.},
  author={Judes Poirier and Jean Davignon and Donald Bouthillier and Simon B. Kogan and P. F. Bertrand and Serge Gauthier},
  volume={342 8873},
Apolipoprotein E (apoE) is associated with Alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques. It also appears to play an important part in the redistribution of lipids that follows deafferentation and neurodegeneration in the brain. The gene for apoE is on chromosome 19, within the genomic region previously associated with late-onset familial Alzheimer's disease (AD). We have studied apoE phenotype expression and the corresponding allele frequencies (epsilon 2… CONTINUE READING
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