Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain.

Abstract

The Apolipoprotein E (ApoE) isotype ApoE4 is a prevalent genetic risk factor for Alzheimer's disease (AD) that can modulate systemic and central inflammation, independent of amyloid accumulation. Although disruption of innate immune toll receptor signaling is modulated by ApoE and observed in AD, ApoE isotype-specific effects remain poorly understood… (More)
DOI: 10.1097/WNR.0000000000000608

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