Apolipoprotein E induces antiinflammatory phenotype in macrophages.

  title={Apolipoprotein E induces antiinflammatory phenotype in macrophages.},
  author={Daniel Baitsch and Hans H. Bock and Thomas Engel and Ralph Telgmann and Carsten M{\"u}ller-Tidow and Georg Varga and Martine Bot and Joachim Herz and Horst Robenek and Arnold von Eckardstein and J R Nofer},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={31 5},
OBJECTIVE Apolipoprotein E (apoE) exerts potent antiinflammatory effects. Here, we investigated the effect of apoE on the functional phenotype of macrophages. METHODS AND RESULTS Human apoE receptors very-low-density lipoprotein receptor (VLDL-R) and apoE receptor-2 (apoER2) were stably expressed in RAW264.7 mouse macrophages. In these cells, apoE downregulated markers of the proinflammatory M1 phenotype (inducible nitric oxide synthase, interleukin [IL]-12, macrophage inflammatory protein-1… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 83 extracted citations


Publications referenced by this paper.
Showing 1-10 of 37 references

CD 4  CD 25  Foxp 3  regulatory T cells induce alternative activation of human monocytes / macrophages

  • MM Tiemessen, AL Jagger, HG Evans, MJ vanHerwijnen, S John, LS Taams
  • Proc Natl Acad Sci U S A
  • 2007

Similar Papers

Loading similar papers…