Apolipoprotein E induces antiinflammatory phenotype in macrophages.

@article{Baitsch2011ApolipoproteinEI,
  title={Apolipoprotein E induces antiinflammatory phenotype in macrophages.},
  author={Daniel Baitsch and Hans H. Bock and Thomas Engel and Ralph Telgmann and Carsten M{\"u}ller-Tidow and Georg Varga and Martine Bot and Joachim Herz and Horst Robenek and Arnold von Eckardstein and J R Nofer},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 5},
  pages={1160-8}
}
OBJECTIVE Apolipoprotein E (apoE) exerts potent antiinflammatory effects. Here, we investigated the effect of apoE on the functional phenotype of macrophages. METHODS AND RESULTS Human apoE receptors very-low-density lipoprotein receptor (VLDL-R) and apoE receptor-2 (apoER2) were stably expressed in RAW264.7 mouse macrophages. In these cells, apoE downregulated markers of the proinflammatory M1 phenotype (inducible nitric oxide synthase, interleukin [IL]-12, macrophage inflammatory protein-1… CONTINUE READING

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