Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis.

@article{Moulard1996ApolipoproteinEG,
  title={Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis.},
  author={Bruno Moulard and Abdelaziz Sefiani and A Laamri and Alain Malafosse and William Camu},
  journal={Journal of the neurological sciences},
  year={1996},
  volume={139 Suppl},
  pages={34-7}
}
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative motor neuron disorder of unknown etiology. Recently, in Alzheimer's disease (AD) apolipoprotein E (APOE) alleles have been shown to play an important role in disease phenotype. To determine whether APOE have a similar influence in other neurodegenerative disorders, we studied APOE genotypes in 130 sporadic ALS patients, compared with controls. We also analyzed APOE genotypes regarding ALS clinical criteria. The frequency of APOE… CONTINUE READING

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