Apolipoprotein E genotypes in Parkinson's disease with and without dementia.

  title={Apolipoprotein E genotypes in Parkinson's disease with and without dementia.},
  author={William C. Koller and S L Glatt and Jean Pintar Hubble and Arcidiacono Paolo and Alexander I Tr{\"o}ster and Monica Handler and Rebecca Thayer Horvat and Cozette Martin and Kathrin Schmidt and Alison M. Karst},
  journal={Annals of neurology},
  volume={37 2},
The apolipoprotein E gene (Apo E) type 4 allele is a genetic risk factor influencing the development and age of onset of Alzheimer's disease. Because Parkinson's disease shares many characteristics of Alzheimer's disease, we studied the frequencies of Apo E genotypes in a cohort of 52 Parkinson's disease patients with dementia and 61 patients without dementia. Dementia was determined per National Institute of Neurological and Communicative Disorders and Stroke criteria and Mattis Dementia… CONTINUE READING