Apolipoprotein E genotype is related to progression of white matter lesion load.

  title={Apolipoprotein E genotype is related to progression of white matter lesion load.},
  author={Ophelia Godin and Christophe Tzourio and Pauline Maillard and Annick Alp{\'e}rovitch and Bernard Mazoyer and Carole Dufouil},
  volume={40 10},
BACKGROUND AND PURPOSE The relationship between white matter lesions (WMLs) and the apolipoprotein E genotype has been controversial from cross-sectional studies and no longitudinal finding has been reported. We investigated whether the apolipoprotein E genotype influences baseline and evolution over 4-year follow-up of WML volumes in a population-based sample of 1779 nondemented subjects aged 65 to 80 years old at enrollment. METHODS The sample consisted of 3C-Dijon study participants who… CONTINUE READING

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