Apolipoprotein E genotype influences cognitive 'phenotype' in patients with Alzheimer's disease but not in healthy control subjects.

@article{Smith1998ApolipoproteinEG,
  title={Apolipoprotein E genotype influences cognitive 'phenotype' in patients with Alzheimer's disease but not in healthy control subjects.},
  author={Glenn E. Smith and Daryl L Bohac and Stephen C. Waring and Emre Kokmen and Eric G. Tangalos and Robert J. Ivnik and Ronald C. Petersen},
  journal={Neurology},
  year={1998},
  volume={50 2},
  pages={355-62}
}
We examined the association of apolipoprotein E (apo E) genotype with cognitive performance in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients and in normal subjects. One hundred fifty-seven AD patients, 35 MCI patients who developed AD during longitudinal follow-up, and 341 normal control subjects from the Mayo Clinic Alzheimer's Disease Patient Registry were studied. All participants were typed for apo E using polymerase chain reaction-based assay, epsilon 4+ and epsilon… CONTINUE READING

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