Apolipoprotein E genotype in patients with Alzheimer's disease.

  title={Apolipoprotein E genotype in patients with Alzheimer's disease.},
  author={Benyan Luo and Zhi Chen and Yanyan Zhang and Xiaoping Pan and Xia Li and Feng Chen},
  journal={Chinese medical journal},
  volume={116 8},
OBJECTIVE To explore the frequency and significance of ApoE gene polymorphisms in patients with sporadic Alzheimer's disease (AD). METHODS Single nucleotide polymorphisms of the ApoE gene were analyzed in 32 cases of AD and 26 controls, using PCR and gene sequencing. RESULTS The single nucleotide polymorphism of ApoE gene 462C/G was significantly associated with AD (P < 0.05). CONCLUSIONS The 462C/G polymorphism might be a specific genotype in Chinese patients with sporadic AD.