Apolipoprotein E genotype, vascular risk and early cognitive impairment in an African Caribbean population.

@article{Stewart2001ApolipoproteinEG,
  title={Apolipoprotein E genotype, vascular risk and early cognitive impairment in an African Caribbean population.},
  author={Robert Stewart and Carsten Russ and M Richards and Carol Brayne and Simon Lovestone and Anthony Mann},
  journal={Dementia and geriatric cognitive disorders},
  year={2001},
  volume={12 4},
  pages={251-6}
}
A reduced risk of Alzheimer's disease (AD) associated with the apolipoprotein E (APOE) epsilon4 allele is reported in populations of African origin. In order to clarify possible reasons for this, we examined the association between APOE genotype and early cognitive impairment in a community-based African Caribbean UK population aged 55-75 years. APOE genotype was available for 202 participants, 57 (28%) of whom were classified as having relative cognitive impairment on a battery of… CONTINUE READING

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