Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin.

@article{Campalani2006ApolipoproteinEG,
  title={Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin.},
  author={Emanuela Campalani and Michael Hugh Allen and David Fairhurst and Helen S Young and Cristina Mendonça and A D Burden and Christopher Griffiths and M. A. Crook and Jonathan N. W. N. Barker and Catherine H Smith},
  journal={The British journal of dermatology},
  year={2006},
  volume={154 2},
  pages={345-52}
}
BACKGROUND Psoriasis is associated with abnormal plasma lipid metabolism and a high frequency of cardiovascular events. Increased lipid levels are also seen in patients with psoriasis treated with acitretin. Apolipoprotein E (ApoE) variants have been linked to hypertriglyceridaemia and hypercholesterolaemia in normal individuals. Two coding single nucleotide polymorphisms at +3937 and +4075 define the three common ApoE alleles e2, e3 and e4. OBJECTIVES To test the hypothesis that particular… CONTINUE READING