Apolipoprotein E expression and purification.

@article{Newhouse2010ApolipoproteinEE,
  title={Apolipoprotein E expression and purification.},
  author={Yvonne N Newhouse and Karl Heinrich Weisgraber},
  journal={Methods in molecular biology},
  year={2010},
  volume={670},
  pages={
          127-40
        }
}
Since the discovery of the association of apolipoprotein E (apoE) 4 with Alzheimer's disease 17 years ago, numerous in vitro experiments with the apoE isoforms (apoE2, apoE3, and apoE4) have been performed to try to understand the basis for this association. The majority of these studies used commercial sources for apoE, but some used recombinant protein. In either case, these studies were most often conducted without considering the ramifications of the structural and biophysical differences… CONTINUE READING
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