Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia.

@article{Agosta2009ApolipoproteinEE,
  title={Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia.},
  author={Federica Agosta and Keith A. Vossel and Bruce L. Miller and Raffaella Migliaccio and Stephen J. Bonasera and Massimo Filippi and Adam L. Boxer and Anna M. Karydas and Katherine L. Possin and Maria Luisa Gorno-Tempini},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 6},
  pages={2018-22}
}
Apolipoprotein epsilon4 (apoE4) has been strongly linked with Alzheimer's disease (AD) and contributes to several other neurological disorders. We investigated the influence of epsilon4 allele carrier status on the pattern of gray matter atrophy and disease severity in 51 patients with probable AD and 31 patients with behavioral variant frontotemporal dementia (bvFTD), compared with 56 healthy controls. Voxel-based morphometry was performed by using statistical parametric mapping. The epsilon4… CONTINUE READING
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