Apolipoprotein E epsilon 4 is associated with hippocampal volume reduction in females with alcoholism.

@article{Bleich2003ApolipoproteinEE,
  title={Apolipoprotein E epsilon 4 is associated with hippocampal volume reduction in females with alcoholism.},
  author={Stefan Bleich and Julia Wilhelm and Elmar Graesel and Detlef Degner and Wolfgang Sperling and Veit R{\"o}\ssner and K. Javaheripour and Johannes Kornhuber},
  journal={Journal of neural transmission},
  year={2003},
  volume={110 4},
  pages={401-11}
}
There is evidence that a higher incidence of diverse neurodegenerative diseases is associated with the apolipoprotein E epsilon4 allele (ApoE4). Most recently it has been found that the ApoE4 allele is specifically related to an accelerated hippocampal atrophy in patients with Alzheimer's disease. Therefore, the aim of the present study was to investigate the association between ApoE4 genotypes and brain hippocampal volume reduction in alcoholics by using volumetric high-resolution MR imaging… CONTINUE READING