Apolipoprotein E epsilon 4 allele and nephrotic glomerular diseases in children.


Hyperlipidemia is a well-recognized complication of the nephrotic syndrome and is a factor contributing to the progression of the initial glomerular injury and the development of glomerulosclerosis. Apolipoprotein E (apoE) is a plasma protein and apoE epsilon 4 allele is associated with higher plasma cholesterol levels. With this in mind, we studied apoE phenotypes and alleles in children with nephrotic glomerular diseases (NGD, n=29), including idiopathic nephrotic syndrome (n=16), membranoproliferative glomerulonephritis (n=7), and focal segmental glomerulosclerosis (FSGS, n=6). Children with NGD had a higher epsilon 4 allele frequency (20.7%) than controls (10.8%), and those with FSGS had both higher apoE4/3 (66.7%) and epsilon 4 allele (33.3%) frequencies than controls (20.4% and 10.8%, respectively). In IgA nephropathy (n=30, disease controls), no significant association with specific apoE was found. Further studies are needed to clarify the significance of the observed high frequencies of apoE epsilon 4 allele in children with NGD and apoE4/3 phenotype distribution in FSGS.


Citations per Year

163 Citations

Semantic Scholar estimates that this publication has 163 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Asami1999ApolipoproteinEE, title={Apolipoprotein E epsilon 4 allele and nephrotic glomerular diseases in children.}, author={Tadashi Asami and Tatiana Ciom{\^a}rtan and Hiroshi Hayakawa and Makoto Uchiyama and Shuichi Tomisawa}, journal={Pediatric nephrology}, year={1999}, volume={13 3}, pages={233-6} }