Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study

@inproceedings{Morgen2015ApolipoproteinEL,
  title={Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study},
  author={Katrin Morgen and Michael H. Schneider and Lutz Fr{\"o}lich and Heike Tost and Michael M. Plichta and Heike Koelsch and Fabian Rakebrandt and Otto Rienhoff and Frank Jessen and Oliver Peters and Holger Jahn and Christian Luckhaus and Michael Huell and H P Gertz and Johannes Schr{\"o}der and Harald Hampel and Stefan J. Teipel and Johannes Pantel and Isabella Heuser and Jens Wiltfang and Eckart Ruether and Johannes Kornhuber and Wolfgang Maier and Andreas Meyer-Lindenberg},
  booktitle={Alzheimer's Research & Therapy},
  year={2015}
}
White matter (WM) magnetic resonance imaging (MRI) hyperintensities are common in Alzheimer’s disease (AD), but their pathophysiological relevance and relationship to genetic factors are unclear. In the present study, we investigated potential apolipoprotein E (APOE)-dependent effects on the extent and cognitive impact of WM hyperintensities in patients with AD. WM hyperintensity volume on fluid-attenuated inversion recovery images of 201 patients with AD (128 carriers and 73 non-carriers of… CONTINUE READING
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Structural Brain Mapping Group, Christian Gaser, Departments of Neurology and Psychiatry, University of Jena, Germany

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  • 2015
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