Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age.

@article{Kok2009ApolipoproteinEA,
  title={Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age.},
  author={Eloise H Kok and Satu Haikonen and Teemu Miikka Artturi Luoto and Heini Sisko Annamari Huhtala and Sirkka Goebeler and Hannu Kalervo Haapasalo and Pekka J. Karhunen},
  journal={Annals of neurology},
  year={2009},
  volume={65 6},
  pages={650-7}
}
OBJECTIVE To study the prevalence and age dependency of senile plaques (SP) and neurofibrillary tangles (NFT), the brain changes characteristic of Alzheimer disease (AD), and their association with apolipoprotein E (APOE) genotypes in a community-dwelling normal population. METHODS This neuropathological study used both silver staining and A beta immunohistochemistry in brain tissue microarrays, including SP coverage and NFT counts from frontal cortex and hippocampus, and APOE genotyping, and… CONTINUE READING

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