Apolipoprotein E and lipoprotein lipase reduce macrophage degradation of oxidized very-low-density lipoprotein (VLDL), but increase cellular degradation of native VLDL.

@article{Keidar1992ApolipoproteinEA,
  title={Apolipoprotein E and lipoprotein lipase reduce macrophage degradation of oxidized very-low-density lipoprotein (VLDL), but increase cellular degradation of native VLDL.},
  author={Shlomo Keidar and Marielle Kaplan and Mira Rosenblat and Gerald J. Brook and Michael Y Aviram},
  journal={Metabolism: clinical and experimental},
  year={1992},
  volume={41 11},
  pages={1185-92}
}
Oxidized low-density lipoprotein (Ox-LDL) has been shown to be taken up by the macrophage-scavenger receptor at an enhanced rate in comparison to native LDL, with consequent cellular cholesterol accumulation. In the present study, we analyzed macrophage interaction with very-low-density lipoprotein (VLDL) from normolipidemic subjects (N-VLDL) that was oxidized in the presence of 10 mumol/L copper ions. Oxidized VLDL (Ox-VLDL) contained increased conjugated dienes and malondialdehyde (MDA… CONTINUE READING

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Interaction of oxidized low density lipoprotein with macrophages in atherosclerosis, and the antiatherogenicity of antioxidants.

European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies • 1996

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