Apolipoprotein E and Alzheimer disease.

  title={Apolipoprotein E and Alzheimer disease.},
  author={Warren J. Strittmatter and A. D. Roses},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 11},
Inheritance of specific apolipoprotein E (apoE) alleles determines, in large part, the risk and mean age of onset of late-onset familial and sporadic Alzheimer disease. The mechanism by which the apoE isoforms differentially contribute to disease expression is, however, unknown. Isoform-specific differences have been identified in the binding of apoE to the microtubule-associated protein tau, which forms the paired helical filament and neurofibrillary tangles, and to amyloid beta peptide, a… CONTINUE READING


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