Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport.

@article{Colton2001ApolipoproteinEA,
  title={Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport.},
  author={Carol A. Colton and Meggan Czapiga and J Snell-Callanan and O. Chernyshev and Michael P Vitek},
  journal={Biochimica et biophysica acta},
  year={2001},
  volume={1535 2},
  pages={134-44}
}
Previous studies have shown that apolipoprotein E (apoE) plays a role in immune function by modulating tissue redox balance. Using a mouse macrophage cell line (RAW 264.7), we have examined the mechanism by which apoE regulates nitric oxide (NO) production in macrophages. ApoE potentiates NO production in immune activated RAW cells in combination with lipopolysaccharide or polyinosinic:polycytidylic acid (PIC), agents known to induce expression of inducible nitric oxide synthase mRNA and… CONTINUE READING
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