Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis.

  title={Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis.},
  author={Scott C. Neu and Judy Pa and Walter Kukull and Duane L. Beekly and Amanda Kuzma and Prabhakaran Gangadharan and Li-San Wang and Klaus Romero and Stephen Arneric and Alberto Redolfi and Daniele Orlandi and Giovanni B. Frisoni and Rhoda Au and Sherral Devine and Sanford H. Auerbach and Ana Carolina Espinosa and Merç{\'e} Boada and Agust{\'i}n Ru{\'i}z and Sterling C. Johnson and Rebecca L. Koscik and Jiun-Jie Wang and Wen-Chuin Hsu and Yao-Liang Chen and Arthur W. Toga},
  journal={JAMA neurology},
  volume={74 10},
Importance It is unclear whether female carriers of the apolipoprotein E (APOE) ε4 allele are at greater risk of developing Alzheimer disease (AD) than men, and the sex-dependent association of mild cognitive impairment (MCI) and APOE has not been established. Objective To determine how sex and APOE genotype affect the risks for developing MCI and AD. Data Sources Twenty-seven independent research studies in the Global Alzheimer's Association Interactive Network with data on nearly 58 000… CONTINUE READING
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